Fly for MS is a public non-profit charity, with 501(c)(3) U.S. Federal tax exempt status.

Contributions to Fly for MS are tax deductible (under section 170 of the U.S. Internal Revenue Code).

The organization is registered in New York City as "Fly for a cause, Inc", and is entirely staffed by volunteers.

Because the U.S. Federal Government provides tax exemptions for contributions made to 501(c)(3) public charities, these entities are highly regulated, following strict rules in both their activity and governance, as well as stringent reporting requirements regarding the use of funds.